As bird flu outbreaks spread among birds and mammals, the U.S. government says it has three FDA-approved H5N1 vaccines in its stockpile. However, experts questioned the effectiveness against current strains and raised concerns about potential side effects.

The vaccines, manufactured by pharmaceutical giants Sanofi, GSK and CSL Seqirus, all contain mercury, a known neurotoxin, according to product inserts. The same companies — plus Moderna — are working to develop new bird flu vaccines. Federal officials said they supply several hundred thousand doses within weeks and 10 million more using materials on hand, and expect to produce 125 million doses within four months.

The product warnings cited adverse events related to the 1976 swine flu vaccine, which included Guillain-Barré syndrome and other neurological disorders such as encephalopathy, optic neuritis/neuropathy, partial facial paralysis and brachial plexus neuropathy, as well as vasculitis and altered immunocompetence.

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