Genomic research of Fusobacterium nucleatum isolated from colon cancer tumors may help researchers develop future screening tests and cancer vaccines

Pinning down colon cancer’s genetic or environmental causes has been a complex and long-running quest, but a new study in Nature points to a promising clue: a bacterium typically found in the human mouth. The study found that a specific subtype, or clade, within a subspecies of Fusobacterium nucleatum was linked to colon cancer growth and progression. These results, the study authors say, could lead to better noninvasive diagnostic methods for colon cancer and could even suggest new therapies targeting these bacteria for tumor elimination.

https://www.scientificamerican.com/article/colon-cancer-linked-to-mouth-bacteria/

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A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche

https://www.nature.com/articles/s41586-024-07182-w