I have been somewhat confused by this concept but here is a real easy to understand explanation

Fully’s Take : The conclusion is…Those who are jabbed will Never be able to produce proper antibodies to control and then prevent future infections with Covid variants. In essence they will be able to get Covid multiple times …forever

By Jeff Childers

A new Stanford study — very carefully and using precise technical language — suggests that the evidence shows the mRNA vaccines could actually be causing original antigenic sin and immune suppression. (Link to the study: https://tinyurl.com/4dv3dse4.)

The term “original antigenic sin” describes a horrible problem with some vaccines, where a vaccine developed from an early viral variant wrecks the body’s ability to deal with any new variants. The vaccine properly teaches the recipients’ bodies to make antibodies specific to that original viral strain. But later, when vaccinated people run into a new variant, their bodies start reflexively making antibodies for the ORIGINAL variant — but not the NEW variant. Since the original early-type antibodies are less or even not at all effective against the new variant, the unfortunate people are at risk of having their systems overwhelmed by a freely replicating virus for which they now have no effective immune response.

In other words, the vaccines themselves freeze the immune system into an ineffective antibody template and prevent the immune system from developing any newer antibodies for an evolving virus. This problem is called “original antigenic sin” or “OAS.”

In the paper, the Stanford researchers refer to the original Covid strain as Wuhan-Hu-1. They found that mRNA-vaccinated people who were subsequently infected by new variant types made plenty of Wuhan-Hu-1 antibodies, but far fewer antibodies for the variant types than unvaccinated people:

> “We find that prior vaccination with Wuhan-Hu-1-like antigens followed by infection with Alpha or Delta variants gives rise to plasma antibody responses with apparent Wuhan-Hu-1-specific imprinting manifesting as relatively *decreased* responses to the variant virus epitopes, compared with unvaccinated patients infected with those variant viruses.”

That’s not good.

The researchers noted that the vaccine makers seem to be aware of the problem, and are working on new jab formulas to accommodate variants. But, if the original vaccines do cause OAS, then the variant boosters might be useless. They may not work at all, or may have limited efficacy or wane even faster than previous boosters, because recipients of the original vaccines already have compromised immune systems.

In dry, technical language, the researchers suggested there should be more study into whether new variant boosters would even work at all, or more ominously, whether they would just make the OAS situation even worse:

> “The extent to which vaccine boosting or infection with different variants will effectively elicit antibody responses to [the] new epitopes or rather [just] increase responses to the [prior] epitopes …, as in the ‘‘original antigenic sin’’ phenomenon described for influenza virus infection and vaccination (Arevalo et al., 2020; Zhang et al., 2019), will be an important topic of ongoing study.”

At this point in the pandemic, it would be insane to start jabbing people with something that could even POSSIBLY freeze people’s immune system response, while we are facing a rapidly mutating virus like Covid. You would think the FDA would make Pfizer and Moderna prove their booster does NOT cause OAS. Oh well.