Goldtent TA Paradise

ADE — claimed to be non issue with rNA ‘vaxx’s

1. pedro_deleon says:

   May 25, 2021 - 9:21 am at 9:21 am

   Early in the pandemic, scientists engaged in a flurry of discussions about the best way to construct COVID-19 vaccines to ensure their efficacy and safety. Some of these discussions centered around antibody-dependent enhancement of immunity (ADE), a potentially deadly immune phenomenon seen with other viral infections and vaccines.

   So far, there have been no reports of ADE with COVID-19 vaccines. But the concerns about ADE with COVID-19 vaccines have resurfaced with the emergency of virus variants. What exactly is ADE? What do we know from past experience with it? And why do experts say it’s a non-issue with COVID-19 vaccines?

   Features of ADE

   While ADE can arise by different pathways, perhaps the best known is the so-called “Trojan Horse” pathway. This occurs when non-neutralizing antibodies generated by past infection or vaccination fail to shut down the pathogen upon re-exposure.

   Instead, they act as a gateway by allowing the virus to gain entry and replicate in cells that are usually off limits (typically immune cells, like macrophages). That, in turn, can lead to wider dissemination of illness, and over-reactive immune responses that cause more severe illness, Barry Bloom, MD, PhD, of the Harvard T.H. Chan School of Public Health, told MedPage Today.

   “The cause of ADE is having antibodies to a virus that don’t neutralize it. That enables the virus to be gobbled up by cells that have receptors for antibodies, but not the virus. That’s the way of getting virus into cells that it ordinarily would not infect,” Bloom said.

   ADE can also occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don’t protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness.

   What Does Past Experience Tell Us About ADE?

   The classic example of Trojan Horse-style ADE comes from dengue. This virus comes in four varieties. They are different enough from each other that past infection with one does not always generate antibodies that match well enough to protect against a different variety.

   ADE has also occurred after vaccination for dengue. For example, in 2016 a dengue vaccine was developed to protect against all four serotypes and given to 800,000 children in the Philippines. Among children who were vaccinated and later exposed to wild-type dengue, 14 died, presumably from more severe illness. Since then, the vaccine has been recommended only to children 9 years and older who have already been exposed to dengue.

   Another classic example comes from the U.S., when ADE occurred during a clinical trial for an inactivated vaccine against respiratory syncytial virus (RSV). In 1967, children who participated in the trial and received the vaccine developed more severe RSV illness when they later encountered the virus in the community. Two toddlers died. The vaccine was associated with immune complex formation that caused lung obstruction and enhanced respiratory disease, pretty much stalling RSV vaccine development.

   Similarly, cases of ADE also occurred with an inactivated measles vaccine that was being developed in the U.S. in the 1960s. After vaccinated children developed more severe illness, the vaccine was withdrawn. The live, weakened measles vaccines that are currently in use in the U.S. have not been associated with ADE.

   ADE a Non-Issue With COVID Vaccines

   Scientists say that ADE is pretty much a non-issue with COVID-19 vaccines, but what are they basing this on?

   From the early stages of COVID-19 vaccine development, scientists sought to target a SARS-CoV-2 protein that was least likely to cause ADE. For example, when they found out that targeting the nucleoprotein of SARS-CoV-2 might cause ADE, they quickly abandoned that approach. The safest route seemed to be targeting the S2 subunit of the spike protein, and they ran with that, wrote Derek Lowe, PhD, in his Science Translational Medicine blog “In the Pipeline.”

   Scientists designed animal studies to look for ADE. They looked for it in human trials, and they’ve been looking for it in the real-world data for COVID-19 vaccines with emergency use authorization. So far, they haven’t seen signs of it. In fact, the opposite is happening, Lowe noted.

   “[W]hat seems to be beyond doubt is that the vaccinated subjects, over and over, show up with no severe coronavirus cases and no hospitalizations. That is the opposite of what you would expect if ADE were happening,” he wrote.

   Furthermore, ADE is an acute problem, and it can be very dramatic. If it was an issue with these vaccines, we would have spotted it by now, said Brian Lichty, PhD, an associate professor in pathology and molecular medicine at McMaster University in Toronto.

   “It’ll kill you quickly. In all the places I’m aware of ADE happening, it is an acute, mostly cytokine-driven event,” he told MedPage Today.

   The one exception may be an inactivated whole-cell, or “killed,” vaccine developed by China. That vaccine uses alum, the same adjuvant that was used in the measles and RSV vaccines that caused ADE in the 1960s. The Chinese inactivated whole-cell vaccine could “conceivably” generate ADE like those older vaccines, according to Bloom.

   “I don’t think that vaccine is ever going to see the light of day in the U.S., and it may not even be worth mentioning. There have been no actual cases of ADE with the Chinese whole-cell killed vaccine, or if so, it hasn’t been reported,” he said.

2. KenS says:

   May 25, 2021 - 10:12 am at 10:12 am

   Thanks for the link. This statement in the article is the reason I have not gotten the Vax:

   “One reason could be that SARS-CoV-2 just may not affect macrophages in a way that can produce ADE, although scientists are still working out the details.”

   Over a billion people vaccinated and the scientists are still working out the details.

3. Fullgoldcrown says:

   May 25, 2021 - 11:10 am at 11:10 am

   THANKS PEDRO…HOPE THIS IS CORRECT

   Need to always consider both sides BUT This in no way justifies Mass Vaccination for a disease with 99.9% survivability…especially in people who had covid and are Immune naturally.

   We still need to wait until the next “season” to rule this out IMO

4. TimH says:

   May 25, 2021 - 12:43 pm at 12:43 pm

   The injection has already shown itself to be deadly, dangerous and also useless. This is in complete contradiction to the manufacturers “safety trials”.