https://advances.sciencemag.org/content/7/27/eabh3032

“Our study has shed unanticipated new light on COVID-19 disease mechanisms and has generated promising drug repurposing opportunities for prophylaxis and treatment. Our data-driven unsupervised approach and biological validation have uncovered 160 approved drugs not currently in clinical trials, which can be investigated immediately for repurposing, and 2 drugs that show promise as antiviral drugs. We expect that this resource of potential drugs will facilitate and accelerate the development of therapeutics against COVID-19. Furthermore, our bespoke data-driven computational approach should be useful for a rapid response to new variants of SARS-CoV-2 and other new pathogens that could drive future pandemics and will also be applicable to other noninfectious disease areas with high unmet medical need.”