“It’s a protein subunit vaccine, meaning it uses nanoparticles of a lab-grown spike protein that mimics the natural spike protein on the surface of the novel coronavirus and which helps the virus bind to cells and cause infection.

When the particles are injected into the body with an adjuvant — a compound that enhances immune response — the body learns to recognize and fight off the virus.

Protein subunit vaccines don’t elicit as strong an immune response as whole virus vaccines, so they often include an adjuvant. Novavax uses a proprietary adjuvant called Matrix-M, which is based on a type of compound found in many plants called a saponin. The company says it boosts the body’s immune response and generates a bigger immune response with a lower dose.

The tried-and-true method of making a custom copy of a virus spike protein has been used to develop vaccines against HPV, hepatitis B and influenza.

The Moderna and Pfizer-BioNTech vaccines, on the other hand, use a newer approach.

Both use messenger RNA (ribonucleic acid) technology, or mRNA, which the Centers for Disease Control says has been studied for more than a decade.

Those vaccines give genetic instructions to the cell on how to make a piece of the spike protein that is unique to the virus that causes COVID-19.”


Robert Malone, MD, MS (LION) on LinkedIn: #Science #Data #honestyisthebestpolicy | 50 comments