The number of U.S. death certificates listing Y59.0, the code for a death caused by a viral vaccine, rose from fewer than 10 per year through 2020, to 198 in 2021, the year COVID-19 vaccines rolled out, according to a new analysis of CDC data by the research group CORRELATION. Researchers described the increase as an unprecedented safety signal, raising questions about vaccine-related mortality reporting, potential underreporting and the need for stronger monitoring systems.

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